Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage
نویسندگان
چکیده
منابع مشابه
Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage
Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens. Since DCs can be modulated depending on the surrounding microenvironment, they can act as a bridge between innate and adaptive immu...
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Dendritic cells (DC) are established T-cell immunity inducers [1], and are also being viewed increasingly as T-cell tolerance mediators [2, 3]. Normally, DCs regulate immune homeostasis by maintaining the balance between T cell immunity and tolerance. Thus far, DC-based immunotherapy has been primarily a consideration in the field of cancer therapy (for the treatment of cancers using fully matu...
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Background: Type-1 diabetes (T1D) is an autoimmune disease in which T lymphocytes destroy insulin-producing β-cells. Control of self-reactive T lymphocytes and recovery of diabetic injury is the end point of T1D. Objective: To investigate generation of tolerogenic dendritic cells (tolDCs) as an innovative method of diabetes therapy. Methods: Lentivirus vector production was achieved by GIPZ mou...
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Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells. In peripheral lymphoid organs DCs also induce tolerance to antigens captured by recep...
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Organ transplantation is the main alternative to the loss of vital organ function from various diseases. However, to avoid graft rejection, transplant patients are treated with immunosuppressive drugs that have adverse side effects. A new emerging approach to reduce the administration of immunosuppressive drugs is to co-treat patients with cell therapy using regulatory cells. In our laboratory,...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2015
ISSN: 2314-8861,2314-7156
DOI: 10.1155/2015/856707